Ovicidal efficacy of fenbendazole after treatment of horses naturally infected with cyathostomins

Daniels, Simon (2016) Ovicidal efficacy of fenbendazole after treatment of horses naturally infected with cyathostomins. Veterinary Parasitology, 227. pp. 151-156.

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Abstract

The ovicidal activity of benzimidazole (BZ) anthelmintics is unique and not seen in other drug classes. Such ovicidal efficacy is not widely reported for equine cyathostomins, nor has this activity been tested in the face of BZ resistance. Although the product label states that fenbendazole is for use against BZ-susceptible cyathostomins, susceptibility testing is rarely performed. In this field-based study, the ovicidal efficacy of fenbendazole in horses (n=39) harbouring BZ-resistant cyathostomins was compared when dosed at 7.5 mg/kg body weight (BW) orally, as a single dose per os (n=21) or daily for five consecutive days in feed (n=18). Suppression of egg hatch rate was observed in the single and five- day treatment groups; a significant difference between pre- and post-treatment egg hatch rates (P<0.05) was observed for three days after treatment with a single dose of fenbendazole (on premises with BZ-resistant cyathostomins), and for three days after treatment for five consecutive days with fenbendazole (on premises with BZ-resistant cyathostomins). Post treatment numbers of eggs and larvae remained significantly lower (P<0.05) than pre-treatment levels to the end of the trial. We conclude that in the face of BZ-resistant cyathostomins the ovicidal effect of fenbendazole persist for three days after both a single oral dose of 7.5 mg/kg per os and after treatment orally for five consecutive daily doses at 7.5 mg/kg in feed.

Item Type:	Article
Keywords:	Benzimidazole, cyathostomin, efficacy, egg hatch assay, ovicidal
Divisions:	Equine Management and Science
Depositing User:	Prof Meriel Moore-Colyer
Date Deposited:	07 Feb 2017 12:45
Last Modified:	19 Oct 2022 15:13
URI:	https://rau.repository.guildhe.ac.uk/id/eprint/15190

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