Antigen array for serological diagnosis and novel allergen identification in severe equine asthma.

White, S, Moore-Colyer, M, Marti, E, Hannant, D, Gerber, V, Couëtil, L, Richard, E and Alcocer, M (2019) Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Scientific reports, 9 (15170). ISSN 2045-2322

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Abstract

Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performancelimiting allergic respiratory disorder which afects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specifc immunoglobulin E (IgE) against a range of environmental proteins. A comprehensive microarray platform was developed to enable the simultaneous detection of allergen-specifc equine IgE in serum against a wide range of putative allergenic proteins. The microarray revealed a plethora of novel pollen, bacteria, mould and arthropod proteins signifcant in the aetiology of sEA. Moreover, the analyses revealed an association between sEA-afected horses and IgE antibodies specifc for proteins derived from latex, which has traditionally been ubiquitous to the horse’s environment in the form of riding surfaces and race tracks. Further work is required to establish the involvement of latex proteins in sEA as a potential risk factor. This work demonstrates a novel and rapid approach to sEA diagnosis, providing a platform for tailored management and the development of allergen-specifc immunotherapy

Item Type: Article
Keywords: Equine asthma
Divisions: Equine Management and Science
Depositing User: Prof Meriel Moore-Colyer
Date Deposited: 17 Apr 2020 12:35
Last Modified: 17 Apr 2020 12:40
URI: https://rau.repository.guildhe.ac.uk/id/eprint/16395

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